The raw materials for the production of gelatin used in empty gelatin capsules come from different animal carcasses such as pigs, cattle, and sheep, and the popular mad cow disease, bird flu, blue-ear disease, foot-and-mouth disease, etc. all come from animals in recent years. When a traceability investigation of a drug is required, it is often difficult to trace the capsule's raw material. Vegetable gum is derived from natural plants, which can better solve the above problems.
The risk of non-adhesion reaction of plant hollow capsules is more reassuring to manufacturers. Plant hollow capsules have strong inertness and are not easy to cross-link with aldehyde-containing drugs. The main component of gelatin capsules is collagen, which is prone to cross-linking reactions with amino acids and aldehyde-containing drugs, resulting in prolonged capsule disintegration time and reduced dissolution rate.
The low water content of plant hollow capsules can have better medicinal effects. The water content of gelatin hollow capsules is between 12.5-17.5%. Gelatin capsules with high water content tend to absorb the water content or be absorbed by the content, making the capsule soft or brittle, affecting the drug itself. The water content of plant hollow capsules is controlled between 5-8%, which is not easy to react with the contents above and can maintain good physical properties such as toughness for contents of different properties.