Hydroxypropyl methylcellulose (HPMC) is a cellulose derivative, which has been used in food and medicine for more than 40 years. It is a medicinal polymer material with a wide range of excellent properties. The application of domestic HPMC in preparations has shown its broad use, such as capsule film coating materials, solid preparation adhesives, or mixed adhesives, and also used to increase the dissolution of drugs.
HPMC is white or slightly yellow powder, odorless, tasteless, has considerable stability to heat, light and humidity, and can be dissolved in water with any pH value below 60C and ethanol, acetone, are acetone, and dioxygen below 70% In the mixed solvent of methane (1:1), it is insoluble in hot water and more than 60% syrup. The above properties can be applied to solid formulation bonding.
Because HPMC has good film-forming properties, moisture resistance and other properties, film coating can be used instead of traditional sugar coating, and it can also be coated with granules or tablets, which shortens the process, reduces tablet weight, and greatly reduces talc powder, and the quality is stable.
The moisture resistance of HPMC can be mixed with hydrophobic materials to change the original moisture resistance and rapid release.
HPMC is applied to mucoadhesives. Mucoadhesive is one of the new dosage forms that are currently being developed. The drug adheres to the mucosal epithelium by means of the special adhesive force of certain polymer materials, which can prolong the residence and release time of the drug at the adhesion site to achieve the target dosing.
HPMC can be used in sustained-release formulations. HPMC can have a variety of specifications, including DOW Chemical Company HPMCK4M, K15M, and other specifications, which can be used in sustained-release preparations of various mechanisms.