After times of medical development and exploration, numerous types of empty capsules have appeared, similar as HPMC empty capsules, natural water-answerable polysaccharide empty capsules, new polypeptide capsules, chitosan capsules, and so on. How do HPMC empty capsules compare to traditional gelatin capsules?
1. Stable strength and wimpiness When the water content of HPMC capsules drops below 1, its strength and wimpiness remain unchanged, so the new HPMC capsules are more suitable for filling some unstable medicines, which will help to ameliorate the Shelf life and shelf life of drugs.
2. Principally no hygroscopic effect Compared with traditional gelatin capsules, the capsules made of HPMC have lower hygroscopicity ( principally no hygroscopic effect), so the capsule shell won't come brittle. In sticky air, the gelatin capsules packaged with"fish-eye bubble" compound paper are fluently broken due to embrittlement, while HPMC capsules can repel humidity, so the yield of"fish-eye bubble" packaging can be greatly bettered.
3. High-temperature resistance HPMC capsules can remain unchanged for 1 time indeed if they're stored in a high-temperature terrain above 40C. Thus, HPMC capsules are more suitable for the production of medicinal capsules in countries with high sticky and hot climates. Dissolution trials were carried out by filling gelatin capsules and HPMC capsules with acetaminophen at 60 °, and the results showed that HPMC capsules had high-temperature forbearance.
4. the bioavailability remains unchanged the bioavailability of HPMC capsules is principally the same as that of traditional gelatin capsules. For illustration, the United States has done a relative test of HPMC capsules and traditional gelatin capsules of two different medicines, "paracetamol" and"vitamin B2". Results There was no significant difference in bioavailability between the two, which suggested that HPMC capsules could be used as a cover for traditional gelatin capsules.